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A plasma proteomic signature links secretome of senescent monocytes to aging- and obesity-related clinical outcomes in humans

2024-08-03

Abstract excerpt

Cellular senescence increases with age and contributes to age-related declines and pathologies. We identified circulating biomarkers of senescence associated with diverse clinical traits in humans to facilitate future non-invasive assessment of individual senescence burden and efficacy testing of novel senotherapeutics. Using a novel nanoparticle-based proteomic workflow, we profiled the senescence-associated secr...

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Literature Corpus work
012fd97e-a155-5972-af47-022d3f7b2305
DOI
10.1101/2024.08.01.24311368
Open publication

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A plasma proteomic signature links secretome of senescent monocytes to aging- and obesity-related clinical outcomes in humansDOI 10.1101/2024.08.01.24311368
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