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Aggressive early-stage lung adenocarcinoma is characterized by epithelial cell plasticity with acquirement of stem-like traits and immune evasion phenotype.

Oncogene - 1 Aug 2021

Melocchi Valentina, Dama Elisa, Mazzarelli Francesco, Cuttano Roberto, Colangelo Tommaso, Di Candia Leonarda, Lugli Enrico, Veronesi Giulia, Pelosi Giuseppe, Ferretti Gian Maria, Taurchini Marco, Graziano Paolo, Bianchi Fabrizio

Abstract excerpt

Lung adenocarcinoma (LUAD) is the main non-small-cell lung cancer diagnosed in ~40-50% of all lung cancer cases. Despite the improvements in early detection and personalized medicine, even a sizable fraction of patients with early-stage LUAD would experience disease relapses and adverse prognosis. Previous reports indicated the existence of LUAD molecular subtypes characterized by specific gene expression and...

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PMID: 34172935
DOI: 10.1038/s41388-021-01909-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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