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Article

Anterior cingulate cortex-related functional hyperconnectivity underlies sensory hypersensitivity in Grin2b-mutant mice.

Molecular psychiatry - 1 Oct 2024

Lee Soowon, Jung Won Beom, Moon Heera, Im Geun Ho, Noh Young Woo, Shin Wangyong, Kim Yong Gyu, Yi Jee Hyun, Hong Seok Jun, Jung Yongwhan, Ahn Sunjoo, Kim Seong-Gi, Kim Eunjoon

Abstract excerpt

Sensory abnormalities are observed in ~90% of individuals with autism spectrum disorders (ASD), but the underlying mechanisms are poorly understood. GluN2B, an NMDA receptor subunit that regulates long-term depression and circuit refinement during brain development, has been strongly implicated in ASD, but whether GRIN2B mutations lead to sensory abnormalities remains unclear. Here, we report that Grin2b-mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38704508
DOI: 10.1038/s41380-024-02572-y
PMCID: PMC11449790

Genes

GRIN2B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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