Article

Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure

2021-12-25

Abstract excerpt

<h4>Background</h4> The excitatory/inhibitory (E/I) imbalance hypothesis posits that an imbalance between excitatory (glutamatergic) and inhibitory (GABAergic) mechanisms underlies the behavioral characteristics of autism spectrum disorder (autism). However, how E/I imbalance arises and how it may differ across autism symptomatology and brain regions is not well understood. <h4>Methods</h4> We used innovative an...

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Literature Corpus work: 127166c4-c438-54fa-9ae3-94d3c70e8fdc
DOI: 10.1101/2021.12.20.473501

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