Synaptic Pruning Deficits and Abnormal Network Integration in Autism Spectrum Disorder

Abstract excerpt

<p>Autism spectrum disorder (ASD) presents a multilayered clinical phenotype encompassing sensory hypersensitivity and hyposensitivity, synesthetic or cross-modal experiences, stress vulnerability, and dissociative or psychotic-like symptoms. The underlying neural mechanisms remain without a unifiedexplanatory framework.This paper reformulates ASD as a coexisting model of local hyperconnectivity arising from defic...

Topics

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• Autistic Disorder
• Cerebral Cortex
• Diagnostic Imaging
• Models, Neurological
• Nerve Fibers, Myelinated
• Nervous System Malformations
• Neural Pathways
• Neurons

Identifiers and source

Literature Corpus work

4360f5c3-02cb-5a1d-8688-1e16ffd922d1

DOI

10.31234/osf.io/trvds_v1