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Article

Grin2b-mutant mice exhibit heightened remote fear via suppressed extinction and chronic amygdalar synaptic and neuronal dysfunction.

Science advances - 19 Sept 2025

Kang Muwon, Kim Seoyeong, Shin Wangyong, Kim Kyungdeok, Jung Yewon, Choi Woochul, Paik Se-Bum, Kim Eunjoon

Abstract excerpt

Individuals with autism spectrum disorders (ASD) frequently show long-lasting traumatic fear memory, but the underlying mechanisms remain unclear. Here, we report that Grin2b-mutant mice carrying a human ASD-risk mutation (Grin2bC456Y/+ mice) show normal acquisition of contextual fear memory but suppressed fear memory extinction and enhanced remote fear memory responses, along with anxiety- and social-related...

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Source

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Identifiers

PMID: 40961189
DOI: 10.1126/sciadv.adr7691
PMCID: PMC12442867

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