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Discovery of immunotherapy targets for pediatric solid and brain tumors by exon-level expression

3 May 2024

Abstract excerpt

Immunotherapy with chimeric antigen receptor T cells for pediatric solid and brain tumors is constrained by available targetable antigens. Cancer-specific exons present a promising reservoir of targets; however, these have not been explored and validated systematically in a pan-cancer fashion. To identify cancer specific exon targets, here we analyze 1532 RNA-seq datasets from 16 types of pediatric solid and...

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PMID: 38702309
DOI: 10.1038/s41467-024-47649-y

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