Article

Cell surface proteomics of patient-derived malignant rhabdoid tumor organoids identifies ROBO1 as potential CAR T cell target for pediatric solid tumors

2025-02-27

Abstract excerpt

Malignant rhabdoid tumors are highly aggressive pediatric malignancies with limited treatment options and poor outcomes. To expand therapeutic options, we employed mass spectrometry-based cell surface proteomics on malignant rhabdoid tumor and patient-matched normal kidney organoids to identify potential CAR T cell targets. Integrating these findings with transcriptomics and protein expression data, we revealed RO...

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Identifiers and source

Literature Corpus work: b74412fc-d78d-5d03-8399-87c996da87b3
DOI: 10.1101/2025.02.23.639405

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