Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer.

doi:10.1038/s41467-024-49944-0

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Article

Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer.

Nature communications - 11 Jul 2024

Forrest Suzanne J, Gupta Hersh, Ward Abigail, Li Yvonne Y, Doan Duong, Al-Ibraheemi Alyaa, Alexandrescu Sanda, Bandopadhayay Pratiti, Shusterman Suzanne, Mullen Elizabeth A, Collins Natalie B, Chi Susan N, Wright Karen D, Kumari Priti, Mazor Tali, Ligon Keith L, Shivdasani Priyanka, Manam Monica, MacConaill Laura E, Ceca Evelina, Benich Sidney N, London Wendy B, Schilsky Richard L, Bruinooge Suanna S, Guidry Auvil Jaime M, Cerami Ethan, Rollins Barrett J, Meyerson Matthew L, Lindeman Neal I, Johnson Bruce E, Cherniack Andrew D, Church Alanna J, Janeway Katherine A

Abstract excerpt

To inform clinical trial design and real-world precision pediatric oncology practice, we classified diagnoses, assessed the landscape of mutations, and identified genomic variants matching trials in a large unselected institutional cohort of solid tumors patients sequenced at Dana-Farber / Boston Children's Cancer and Blood Disorders Center. Tumors were sequenced with OncoPanel, a targeted next-generation DNA...

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PMID: 38992034
DOI: 10.1038/s41467-024-49944-0
PMCID: PMC11239876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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