Article

Cell surface proteomics of patient-derived malignant rhabdoid tumor organoids identifies ROBO1 as promising CAR T cell target for pediatric solid tumors

2025-03-24

Abstract excerpt

<title>Abstract</title> <p>Malignant rhabdoid tumors are highly aggressive pediatric malignancies with limited treatment options and poor outcomes. To expand therapeutic options, we employed mass spectrometry-based cell surface proteomics on malignant rhabdoid tumor and patient-matched normal kidney organoids to identify potential CAR T cell targets. Integrating these findings with transcriptomics and protein exp...

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Literature Corpus work: 338e2db3-8404-56c2-b6a1-be9a6752d152
DOI: 10.21203/rs.3.rs-6111378/v1

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