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A two-layer assay for single-nucleotide variants utilizing strand displacement and selective digestion.

Biosensors & bioelectronics - 15 Aug 2016

Yu Yingjie, Wu Tongbo, Johnson-Buck Alexander, Li Lidan, Su Xin

Abstract excerpt

Point mutations have emerged as prominent biomarkers for disease diagnosis, particularly in the case of cancer. Discovering single-nucleotide variants (SNVs) is also of great importance for the identification of single-nucleotide polymorphisms within the population. The competing requirements of thermodynamic stability and specificity in conventional nucleic acid hybridization probes make it challenging to...

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PMID: 27100949
DOI: 10.1016/j.bios.2016.03.070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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