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A comprehensive system for detecting rare single nucleotide variants based on competitive DNA probe and duplex-specific nuclease.

Analytica chimica acta - 29 Jun 2021

Zhang Li, Wang Yufeng, Guo Yongcan, Chen Huajian, Yu Wen, Zhang Zhang, Xie Guoming

Abstract excerpt

Single nucleotide variants (SNVs) have emerged as increasingly important biomarkers, particularly in the diagnosis and prognosis of cancers. However, most SNVs are rarely detected in blood samples from cancer patients as they are surrounded by abundant concomitant wild-type nucleic acids. Herein, we design a system that features a combination of competitive DNA probe system (CDPS) and duplex-specific nuclease...

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PMID: 34023002
DOI: 10.1016/j.aca.2021.338545

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