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Programmable One-Pot Enzymatic Reaction for Direct Fluorescence Detection of Ultralow-Abundance Mutations in the DNA Duplex.

Analytical chemistry - 11 May 2021

Yang Ziyu, Chen Wei, Wang Jiayu, Shi Minghe, Zhang Ruilan, Dai Shenbin, Wu Tongbo, Zhao Meiping

Abstract excerpt

Sensitive detection of low-abundance driver mutations may provide valuable information for precise clinical treatment. Compared to next-generation sequencing and droplet digital PCR methods, fluorescent probes show great flexibility in rapid detection of specific mutations with high sensitivity and easily accessible instruments. However, existing approaches with fluorescent probes need an additional step to...

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Diagnostic Tests, Routine
DNA
DNA, Single-Stranded
Exons
Mutation

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PMID: 33901400
DOI: 10.1021/acs.analchem.1c00564

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