A polygenetic risk score combined with environmental factors better predict susceptibility to hepatocellular carcinoma in Chinese population.

doi:10.1002/cam4.7230

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Article

A polygenetic risk score combined with environmental factors better predict susceptibility to hepatocellular carcinoma in Chinese population.

Cancer medicine - 1 May 2024

Zou Yuanlin, Zhu Jicun, Song Caijuan, Li Tiandong, Wang Keyan, Shi Jianxiang, Ye Hua, Wang Peng

Abstract excerpt

AIMS: This study aimed to investigate environmental factors and genetic variant loci associated with hepatocellular carcinoma (HCC) in Chinese population and construct a weighted genetic risk score (wGRS) and polygenic risk score (PRS). METHODS: A case-control study was applied to confirm the single nucleotide polymorphisms (SNPs) and environmental variables linked to HCC in the Chinese population, which had been...

Topics

Humans
Carcinoma, Hepatocellular
Liver Neoplasms
Polymorphism, Single Nucleotide
Genetic Predisposition to Disease
Case-Control Studies
Male
Female
Middle Aged
China

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Risk Assessment

Multifactorial Inheritance

Aged

Gene-Environment Interaction

East Asian People

Source

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Identifiers

PMID: 38698686
DOI: 10.1002/cam4.7230
PMCID: PMC11066500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-38698686-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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