Individualized Polygenic Risk Score Identifies NASH in the Eastern Asia Region: A Derivation and Validation Study.

doi:10.14309/ctg.0000000000000321

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Article

Individualized Polygenic Risk Score Identifies NASH in the Eastern Asia Region: A Derivation and Validation Study.

Clinical and translational gastroenterology - 10 Mar 2021

Gao Feng, Zheng Kenneth I, Chen Sui-Dan, Lee Dong Hyeon, Wu Xi-Xi, Wang Xiao-Dong, Targher Giovanni, Byrne Christopher D, Chen Yong-Ping, Kim Won, Zheng Ming-Hua

Abstract excerpt

INTRODUCTION: Strong evidence indicates that multiple genetic and environmental risk factors play a role in the pathogenesis of nonalcoholic steatohepatitis (NASH). We aimed to develop and validate a novel nomogram, incorporating both genetic and clinical factors, for predicting NASH. METHODS: A total of 1,070 Asian individuals with biopsy-confirmed nonalcoholic fatty liver disease (NAFLD) from 2 countries (China...

Topics

17-Hydroxysteroid Dehydrogenases
Adult
Biopsy
China
Cross-Sectional Studies
Female
Genetic Predisposition to Disease
Humans
Insulin Resistance
Lipase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver

Male

Membrane Proteins

Metabolic Syndrome

Middle Aged

Nomograms

Non-alcoholic Fatty Liver Disease

Polymorphism, Single Nucleotide

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Identifiers

PMID: 33704100
DOI: 10.14309/ctg.0000000000000321
PMCID: PMC7954375

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