The association between single-nucleotide polymorphisms within type 1 interferon pathway genes and human immunodeficiency virus type 1 viral load in antiretroviral-naïve participants.

doi:10.1186/s12981-024-00610-x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The association between single-nucleotide polymorphisms within type 1 interferon pathway genes and human immunodeficiency virus type 1 viral load in antiretroviral-naïve participants.

AIDS research and therapy - 3 May 2024

Mørup Sara Bohnstedt, Leung Preston, Reilly Cavan, Sherman Brad T, Chang Weizhong, Milojevic Maja, Milinkovic Ana, Liappis Angelike, Borgwardt Line, Petoumenos Kathy, Paredes Roger, Mistry Shweta S, MacPherson Cameron R, Lundgren Jens, Helleberg Marie, Reekie Joanne, Murray Daniel D

Abstract excerpt

BACKGROUND: Human genetic contribution to HIV progression remains inadequately explained. The type 1 interferon (IFN) pathway is important for host control of HIV and variation in type 1 IFN genes may contribute to disease progression. This study assessed the impact of variations at the gene and pathway level of type 1 IFN on HIV-1 viral load (VL). METHODS: Two cohorts of antiretroviral (ART) naïve participants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4 Lymphocyte Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Disease Progression

Share to HIV-1

Share to HIV Infections

Share to Interferon Type I

Share to Receptor, Interferon alpha-beta

Share to Viral Load

Source

Open in PubMed Open full text

Identifiers

PMID: 38698440
DOI: 10.1186/s12981-024-00610-x
PMCID: PMC11067292

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The association between single-nucleotide polymorphisms within type 1 interferon pathway genes and human immunodeficiency virus type 1 viral load in antiretroviral-naïve participants.PMID 38698440Read ↗

Interferon regulatory factor 1 polymorphisms previously associated with reduced HIV susceptibility have no effect on HIV disease progression.Semantic proximity Read ↗

Targeted next-generation sequencing approach for CCR5, CXCR4 and IFNAR1 genes in HIV+ participants: Association of single nucleotide polymorphisms with CD4+ T cell count and HIV replication in patients receiving antiretroviral therapySemantic proximity Read ↗

Omics Integration Uncovers Mechanisms Associated with HIV Viral Load and Potential Therapeutic InsightsSemantic proximity Read ↗

Interferon lambda rs368234815 ΔG/ΔG is associated with higher CD4+:CD8+ T-cell ratio in treated HIV-1 infection.Semantic proximity Read ↗

Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy–Naive Participants From the Strategic Timing of AntiRetroviral Treatment TrialSemantic proximity Read ↗

Host variation in type I interferon signaling genes (MX1), C-C chemokine receptor type 5 gene, and major histocompatibility complex class I alleles in treated HIV+ noncontrollers predict viral reservoir size.Semantic proximity Read ↗

Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study.Semantic proximity Read ↗

Functional Role of Single-Nucleotide Polymorphisms on IFNG and IFNGR1 in Humans with Cardiovascular Disease.Semantic proximity Read ↗

Multiple Homozygous Variants in the STING-Encoding TMEM173 Gene in HIV Long-Term Nonprogressors.Semantic proximity Read ↗

Antagonistic role of IL-1ß and NLRP3/IL-18 genetics in chronic HIV-1 infection.Semantic proximity Read ↗

IFNL4 rs368234815 polymorphism is associated with innate resistance to HIV-1 infection.Semantic proximity Read ↗

Evaluating the Impact of Functional Genetic Variation on HIV-1 Control.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.