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Article

Interferon regulatory factor 1 polymorphisms previously associated with reduced HIV susceptibility have no effect on HIV disease progression.

PloS one - 1 Jan 2013

Sivro Aida, McKinnon Lyle R, Ji Hezhao, Kimani Joshua, Jaoko Walter, Plummer Francis A, Su Ruey-Chyi, Ball T Blake

Abstract excerpt

INTRODUCTION: Interferon regulatory factor 1 (IRF1) is induced by HIV early in the infection process and serves two functions: transactivation of the HIV-1 genome and thus replication, and eliciting antiviral innate immune responses. We previously described three IRF1 polymorphisms that correlate with reduced IRF1 expression and reduced HIV susceptibility. OBJECTIVE: To determine whether IRF1 polymorphisms...

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Identifiers

PMID: 23799084
DOI: 10.1371/journal.pone.0066253
PMCID: PMC3683001

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