Article
Host variation in type I interferon signaling genes (MX1), C-C chemokine receptor type 5 gene, and major histocompatibility complex class I alleles in treated HIV+ noncontrollers predict viral reservoir size.
AIDS (London, England) - 1 Mar 2023
Siegel David A, Thanh Cassandra, Wan Eunice, Hoh Rebecca, Hobbs Kristen, Pan Tony, Gibson Erica A, Kroetz Deanna L, Martin Jeffrey, Hecht Frederick, Pilcher Christopher, Martin Maureen, Carrington Mary, Pillai Satish, Busch Michael P, Stone Mars, Levy Claire N, Huang Meei-Li, Roychoudhury Pavitra, Hladik Florian, Jerome Keith R, Kiem Hans-Peter, Henrich Timothy J, Deeks Steven G, Lee Sulggi A
Abstract excerpt
OBJECTIVE: Prior genomewide association studies have identified variation in major histocompatibility complex (MHC) class I alleles and C-C chemokine receptor type 5 gene (CCR5Δ32) as genetic predictors of viral control, especially in 'elite' controllers, individuals who remain virally suppressed in the absence of therapy. DESIGN: Cross-sectional genomewide association study. METHODS: We analyzed custom whole...
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