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Article

Multiple Homozygous Variants in the STING-Encoding TMEM173 Gene in HIV Long-Term Nonprogressors.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2018

Nissen Sara K, Pedersen Jesper G, Helleberg Marie, Kjær Kathrine, Thavachelvam Karthiga, Obel Niels, Tolstrup Martin, Jakobsen Martin R, Mogensen Trine H

Abstract excerpt

Among HIV-infected individuals, long-term nonprogressor (LTNP) patients experience slow CD4 T cell decline and almost undetectable viral load for several years after primary acquisition of HIV. Type I IFN has been suggested to play a pathogenic role in HIV pathogenesis, and therefore diminished IFN responses may underlie the LTNP phenotype. In this study, we examined the presence and possible immunological role...

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PMID: 29632140
DOI: 10.4049/jimmunol.1701284

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