Article
Carcinogenesis of Pancreatic Ductal Adenocarcinoma.
Gastroenterology - 1 Jun 2020
Storz Peter, Crawford Howard C
Abstract excerpt
Although the estimated time for development of pancreatic ductal adenocarcinoma (PDA) is more than 20 years, PDAs are usually detected at late, metastatic stages. PDAs develop from duct-like cells through a multistep carcinogenesis process, from low-grade dysplastic lesions to carcinoma in situ and eventually to metastatic disease. This process involves gradual acquisition of mutations in oncogenes and tumor...
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