Article
E-M349E and NS2A/2B-P1(T) are compensatory mutations of rDTMUV-NS2AB-P1P1'(AA), which regain virus proliferation by enhancing the virus package and restoring NS2A/2B cleavage.
Virology - 1 Jul 2024
Jiang Bowen, Zhang Wei, Hu Tao, He Yu, Wu Zhen, Wang Mingshu, Jia Renyong, Zhu Dekang, Liu Mafeng, Zhao Xinxin, Yang Qiao, Wu Ying, Zhang Shaqiu, Huang Juan, Mao Sai, Ou Xumin, Sun Di, Zhang Ling, Yu YanLing, Pan Xin, Zhong Jingyi, Cheng Anchun, Chen Shun
Abstract excerpt
Duck Tembusu virus (DTMUV) belongs to the Flaviviridae family and mainly infects ducks. The genome of DTMUV is translated into a polyprotein, which is further cleaved into several protein by viral NS2B3 protease and host proteases. Crucially, the cleavage of the NS2A/2B precursor during this process is essential for the formation of replication complexes and viral packaging. Previous research has demonstrated...
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