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Article

Basic Amino Acid Substitution at Residue 367 of the Envelope Protein of Tembusu Virus Plays a Critical Role in Pathogenesis.

Journal of virology - 31 Mar 2020

Sun Mengxu, Zhang Lijiao, Cao Yanxin, Wang Jun, Yu Ziding, Sun Xue, Liu Fengli, Li Zhuolin, Liu Pinghuang, Su Jingliang

Abstract excerpt

Tembusu virus (TMUV) is a flavivirus responsible for panzootic outbreaks of severe egg-drop and fatal encephalitis of domestic waterfowl in China. Although TMUV can be attenuated by in vitro passaging, experimental evidence supporting the role of specific genetic changes in virulence attenuation is currently lacking. Here, we performed site-directed mutagenesis on five envelope (E) protein amino acid residues in...

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Identifiers

PMID: 32024774
DOI: 10.1128/JVI.02011-19
PMCID: PMC7108846

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