Article
Methyltransferase-Deficient Avian Flaviviruses Are Attenuated Due to Suppression of Viral RNA Translation and Induction of a Higher Innate Immunity.
Frontiers in immunology - 1 Jan 2021
Wu Xuedong, Zhang Yuetian, Wang Mingshu, Chen Shun, Liu Mafeng, Zhu Dekang, Zhao Xinxin, Wu Ying, Yang Qiao, Zhang Shaqiu, Huang Juan, Ou Xumin, Zhang Ling, Liu Yunya, Yu Yanling, Gao Qun, Mao Sai, Sun Di, Tian Bin, Yin Zhongqiong, Jing Bo, Cheng Anchun, Jia Renyong
Abstract excerpt
The 5' end of the flavivirus genome contains a type 1 cap structure formed by sequential N-7 and 2'-O methylations by viral methyltransferase (MTase). Cap methylation of flavivirus genome is an essential structural modification to ensure the normal proliferation of the virus. Tembusu virus (TMUV) (genus Flavivirus) is a causative agent of duck egg drop syndrome and has zoonotic potential. Here, we identified the...
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