Article
Determinants of duck Tembusu virus NS2A/2B polyprotein procession attenuated viral replication and proliferation in vitro.
Scientific reports - 24 Jul 2020
Jiang Bowen, Zhang Wei, Wu Yuanyuan, Wang Tao, Wang Mingshu, Jia Renyong, Zhu Dekang, Liu Mafeng, Zhao Xinxin, Yang Qiao, Wu Ying, Zhang ShaQiu, Liu YunYa, Zhang Ling, Yu YanLing, Pan Leichang, Chen Shun, Cheng Anchun
Abstract excerpt
Duck Tembusu virus (DTMUV), a mosquito-borne Flavivirus, has caused serious economic losses for the Chinese poultry industry. The genome is translated into a polyprotein that is cleaved to mature protein by host and viral proteases in the host cell, and this proteolytic process is important for the viral life cycle. However, the cleavage mechanism of DTMUV polyprotein is still unclear. In this study, we...
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