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Article

Amino Acid Substitutions in NS5 Contribute Differentially to Tembusu Virus Attenuation in Ducklings and Cell Cultures.

Viruses - 16 May 2021

Sun Xue, Sun Mengxu, Zhang Lijiao, Yu Ziding, Li Jinxin, Xie Wanying, Su Jingliang

Abstract excerpt

Tembusu virus (TMUV), a highly infectious pathogenic flavivirus, causes severe egg-drop and encephalitis in domestic waterfowl, while the determinants responsible for viral pathogenicity are largely unknown. In our previous studies, virulent strain JXSP2-4 had been completely attenuated by successive passages in BHK-21 cells and the avirulent strain was designated as JXSP-310. Based on the backbone of JXSP2-4, a...

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Identifiers

PMID: 34065634
DOI: 10.3390/v13050921
PMCID: PMC8156267

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