The A487 residue in the E protein of duck Tembusu virus significantly enhances viral replication and increases its neurovirulence in Kunming mice

Abstract excerpt

ABSTRACT Tembusu virus (TMUV), an emerging avian orthoflavivirus, causes severe egg-drop syndrome and encephalitis in ducks. Although ducks are the natural host, mice serve as a valuable model for studying neuropathogenesis, as TMUV-infected mice recapitulate key neurological symptoms observed in ducks, such as paralysis and encephalitis. In the previous study, we observed that the TMUV strain CQW1 exhibited...

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