Article
The greasy finger region of DTMUV NS1 plays an essential role in NS1 secretion and viral proliferation.
Poultry science - 1 Dec 2024
Tan Hantai, Zhang Senzhao, Wu Zhen, He Yu, Wang Tao, Tan Wangyang, Tang Xuedan, Li Wei, Wang Mingshu, Jia Renyong, Zhu Dekang, Liu Mafeng, Zhao Xinxin, Yang Qiao, Wu Ying, Zhang Shaqiu, Huang Juan, Ou Xumin, Sun Di, Tian Bin, Cheng Anchun, Chen Shun
Abstract excerpt
Duck Tembusu virus (DTMUV) of the Orthoflavivirus genus poses a significant threat to waterfowl aquaculture. Nonstructural protein 1 (NS1), a multifunctional glycoprotein, exists in various oligomeric forms and performs diverse functions. The greasy finger (GF) region within NS1 of other flaviviruses has been shown to be a crucial component of the hydrophobic protrusion aiding in anchoring NS1 to the endoplasmic...
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