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Article

Effect of the leptin receptor Q223R polymorphism on the host transcriptome following infection with Entamoeba histolytica.

Infection and immunity - 1 May 2013

Mackey-Lawrence Nicole M, Guo Xiaoti, Sturdevant Daniel E, Virtaneva Kimmo, Hernandez Matthew M, Houpt Eric, Sher Alan, Porcella Stephen F, Petri William A

Abstract excerpt

Resistance to amebiasis is associated with a polymorphism in the leptin receptor. Previous studies demonstrated that humans with the ancestral Q223 leptin receptor allele were nearly four times less likely to be infected with Entamoeba histolytica than those carrying the mutant R223 allele. We hy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23429533
DOI: 10.1128/IAI.01383-12
PMCID: PMC3647980

Genes

CXCL2
LEPR
MMP9
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23429533-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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