Article
Functional polymorphisms in the gene encoding macrophage migration inhibitory factor are associated with Gram-negative bacteremia in older adults.
The Journal of infectious diseases - 1 Mar 2014
Das Rituparna, Subrahmanyan Lakshman, Yang Ivana V, van Duin David, Levy Rebecca, Piecychna Marta, Leng Lin, Montgomery Ruth R, Shaw Albert, Schwartz David A, Bucala Richard
Abstract excerpt
Macrophage migration inhibitory factor (MIF) is an immune mediator encoded in a functionally polymorphic locus. We found the genotype conferring low expression of MIF to be enriched in a cohort of 180 patients with gram-negative bacteremia, compared with 229 healthy controls (odds ratio [OR], 2.4; P = .04), an association that was more pronounced in older adults (OR, 4.6; P = .01). Among older subjects, those...
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