Article
Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease.
Inflammatory bowel diseases - 1 Jan 2007
Dambacher Julia, Staudinger Tanja, Seiderer Julia, Sisic Zeljka, Schnitzler Fabian, Pfennig Simone, Hofbauer Katrin, Konrad Astrid, Tillack Cornelia, Otte Jan-Michel, Diebold Joachim, Göke Burkhard, Ochsenkühn Thomas, Lohse Peter, Brand Stephan
Abstract excerpt
BACKGROUND: Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with increased expression in inflammatory bowel disease. The aim of the study was to analyze the role of the MIF -173G/C single nucleotide polymorphism in Crohn's disease (CD). METHODS: Using restriction fragment length polymorphism analysis, genomic DNA of 198 patients with CD and 159 unrelated controls was analyzed for the...
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