SLC26A11 is an atypical solute carrier with dual transport-channel function mediating lysosomal sulfate transport

Abstract excerpt

Membrane transporters and channels are generally assumed to be based on distinct structural and functional principles. SLC26A11, a solute carrier with high expression levels in the brain, has been proposed to function as either an anion transporter or a channel. Here, we resolve this apparent discrepancy by demonstrating that SLC26A11 is a dual-function protein capable of operating as both a sulfate transporter an...

Topics

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• Binding Sites
• Cryoelectron Microscopy
• HEK293 Cells
• Models, Molecular
• Protein Binding
• Protein Multimerization
• Sulfate Transporters
• Sulfates

Identifiers and source

Literature Corpus work

8fedd066-ee29-5d90-ae52-4ef118c38599

DOI

10.1101/2025.08.17.670773