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Article

Cell coupling compensates for changes in single-cell Her6 dynamics and provides phenotypic robustness.

Development (Cambridge, England) - 15 May 2024

Doostdar Parnian, Hawley Joshua, Chopra Kunal, Marinopoulou Elli, Lea Robert, Arashvand Kiana, Biga Veronica, Papalopulu Nancy, Soto Ximena

Abstract excerpt

This paper investigates the effect of altering the protein expression dynamics of the bHLH transcription factor Her6 at the single-cell level in the embryonic zebrafish telencephalon. Using a homozygote endogenous Her6:Venus reporter and 4D single-cell tracking, we show that Her6 oscillates in neural telencephalic progenitors and that the fusion of protein destabilisation (PEST) domain alters its expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38682303
DOI: 10.1242/dev.202640
PMCID: PMC11190438

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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