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Article

An ensemble-averaged, cell density-based digital model of zebrafish embryo development derived from light-sheet microscopy data with single-cell resolution.

Scientific reports - 25 Feb 2015

Kobitski Andrei Y, Otte Jens C, Takamiya Masanari, Schäfer Benjamin, Mertes Jonas, Stegmaier Johannes, Rastegar Sepand, Rindone Francesca, Hartmann Volker, Stotzka Rainer, García Ariel, van Wezel Jos, Mikut Ralf, Strähle Uwe, Nienhaus G Ulrich

Abstract excerpt

A new era in developmental biology has been ushered in by recent advances in the quantitative imaging of all-cell morphogenesis in living organisms. Here we have developed a light-sheet fluorescence microscopy-based framework with single-cell resolution for identification and characterization of subtle phenotypical changes of millimeter-sized organisms. Such a comparative study requires analyses of entire...

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Identifiers

PMID: 25712513
DOI: 10.1038/srep08601
PMCID: PMC5390106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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