Article

Single-cell FM streaming using genetically encoded protein oscillators

2025-02-28

Abstract excerpt

Wireless devices use frequency modulation (FM) to reliably transmit information. Here, we establish a biochemical analogue of this paradigm using genetically encoded protein oscillators (GEOs) as carrier signals for real-time streaming of single-cell data. The GEO platform leverages evolutionarily diverse MinDE-family ATPase and Activator modules to generate fast synthetic protein oscillations in cells, where the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 64a4fee6-30bc-5a34-8fcf-f33a21349cc8
DOI: 10.1101/2025.02.28.640587

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell FM streaming using genetically encoded protein oscillatorsDOI 10.1101/2025.02.28.640587Read

Multiplexed, scalable analog recording of gene regulation dynamics over weeks using intracellular protein tapesSemantic proximity Read

Sources of Variability in a Synthetic Gene Oscillator.Semantic proximity Read

ARTEMIS integrates autoencoders and Schrödinger Bridges to predict continuous dynamics of gene expression, cell population and perturbation from time-series single-cell dataSemantic proximity Read

GeneRhythm uncovers gene expression rhythms that shape the dynamic transcriptional landscape in single-cell omicsSemantic proximity Read

Decoding calcium oscillation frequency in transcriptional regulationSemantic proximity Read

Reaction-diffusion condensation generates a regulatable landscape for self-organizing subcellular structuresSemantic proximity Read

Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamicsSemantic proximity Read

Large-scale synthetic data enable digital twins of human excitable cellsSemantic proximity Read

Programmable Organoids and the Emergence of Engineered Genetic and Epigenetic Circuitry in Human DevelopmentSemantic proximity Read

MitoScribe single-cell molecular recorder logs graded signaling dynamics into mitochondrial DNASemantic proximity Read

Collective behavior in gene regulation: the cell is an oscillator, the cell cycle a developmental process.Semantic proximity Read

Variability of bacterial behavior in the mammalian gut captured using a growth-linked single-cell synthetic gene oscillatorSemantic proximity Read