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Article

Topology and dynamics of the zebrafish segmentation clock core circuit.

PLoS biology - 1 Jan 2012

Schröter Christian, Ares Saúl, Morelli Luis G, Isakova Alina, Hens Korneel, Soroldoni Daniele, Gajewski Martin, Jülicher Frank, Maerkl Sebastian J, Deplancke Bart, Oates Andrew C

Abstract excerpt

During vertebrate embryogenesis, the rhythmic and sequential segmentation of the body axis is regulated by an oscillating genetic network termed the segmentation clock. We describe a new dynamic model for the core pace-making circuit of the zebrafish segmentation clock based on a systematic biochemical investigation of the network's topology and precise measurements of somitogenesis dynamics in novel genetic...

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Identifiers

PMID: 22911291
DOI: 10.1371/journal.pbio.1001364
PMCID: PMC3404119

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