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Article

[Advances in development of gene-gene interaction analysis methods based on SNP data: a review].

Yi chuan = Hereditas - 1 Dec 2013

Luan Yi-Zhao, Zuo Xiao-Yu, Liu Ke, Li Gu, Rao Shao-Qi

Abstract excerpt

The SNP-based association analysis has become one of the most important approaches to interpret the underlying molecular mechanisms for human complex diseases. Nevertheless, the widely-used singe-locus analysis is only capable of capturing a small portion of susceptible SNPs with prominent marginal effects, leaving the important genetic component, epistasis or joint effects, to be undetectable. Identifying the...

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PMID: 24645342
DOI: 10.3724/sp.j.1005.2013.01331

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