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Article

Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice.

Journal of hepatology - 1 Nov 2012

Urbanik Toni, Boger Regina Johanna, Longerich Thomas, Becker Katharina, Ehrenberg Karl Roland, Hövelmeyer Nadine, Hahn Matthias, Schuchmann Marcus, Jäger Dirk, Waisman Ari, Wörns Marcus Alexander, Schulze-Bergkamen Henning

Abstract excerpt

BACKGROUND & AIMS: CYLD is a tumor suppressor gene that is mutated in familial cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. Reduced CYLD expression has been observed in other tumor entities, including hepatocellular carcinoma. In the present study, we analyz...

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Source

Identifiers

PMID: 22728872
DOI: 10.1016/j.jhep.2012.06.017

Genes

CYLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22728872-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice.PMID 22728872Read ↗

Cylindromatosis gene CYLD regulates hepatocyte growth factor expression in hepatic stellate cells through interaction with histone deacetylase 7Semantic proximity Read ↗

Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice.Semantic proximity Read ↗

CYLD-Mediated Signaling and DiseasesSemantic proximity Read ↗

CYLD regulates keratinocyte differentiation and skin cancer progression in humansSemantic proximity Read ↗

A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defense.Semantic proximity Read ↗

Five-Lipoxygenase-Activating Protein Mediated CYLD Attenuation is a Candidate Driver in Hepatic Malignant LesionSemantic proximity Read ↗

Cylindromatosis and the <i>CYLD</i> gene: new lessons on the molecular principles of epithelial growth controlSemantic proximity Read ↗

The cylindromatosis (CYLD) gene and head and neck tumorigenesisSemantic proximity Read ↗

Reduced expression of CYLD in human colon and hepatocellular carcinomasSemantic proximity Read ↗

Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation.Semantic proximity Read ↗

The tumour suppressor CYLD regulates the p53 DNA damage response.Semantic proximity Read ↗

The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate Notch signallingSemantic proximity Read ↗

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