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Article

A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defense.

Development (Cambridge, England) - 1 Jul 2007

Tsichritzis Theodore, Gaentzsch Peer C, Kosmidis Stylianos, Brown Anthony E, Skoulakis Efthimios M, Ligoxygakis Petros, Mosialos George

Abstract excerpt

The cylindromatosis (CYLD) gene is mutated in human tumors of skin appendages. It encodes a deubiquitylating enzyme (CYLD) that is a negative regulator of the NF-kappaB and JNK signaling pathways, in vitro. However, the tissue-specific function and regulation of CYLD in vivo are poorly understood. We established a genetically tractable animal model to initiate a systematic investigation of these issues by...

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Identifiers

PMID: 17553907
DOI: 10.1242/dev.02859

Genes

CYLD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defense.PMID 17553907Read ↗

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Cylindromatosis and the <i>CYLD</i> gene: new lessons on the molecular principles of epithelial growth controlSemantic proximity Read ↗

CYLD-Mediated Signaling and DiseasesSemantic proximity Read ↗

Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation.Semantic proximity Read ↗

Thymocyte-specific truncation of the deubiquitinating domain of CYLD impairs positive selection in a NF-kappaB essential modulator-dependent manner.Semantic proximity Read ↗

Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila.Semantic proximity Read ↗

Identification of the familial cylindromatosis tumour-suppressor gene.Semantic proximity Read ↗

The Tumor Suppressor CYLD Interacts with TRIP and Regulates Negatively Nuclear Factor κB Activation by Tumor Necrosis FactorSemantic proximity Read ↗

The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate Notch signallingSemantic proximity Read ↗

CYLD regulates keratinocyte differentiation and skin cancer progression in humansSemantic proximity Read ↗

Truncation of the Catalytic Domain of the Cylindromatosis Tumor Suppressor Impairs Lung MaturationSemantic proximity Read ↗

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