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Article

Polygenic scores for longitudinal prediction of incident type 2 diabetes in an ancestrally and medically diverse primary care physician network: a patient cohort study.

Genome medicine - 26 Apr 2024

Mandla Ravi, Schroeder Philip, Porneala Bianca, Florez Jose C, Meigs James B, Mercader Josep M, Leong Aaron

Abstract excerpt

BACKGROUND: The clinical utility of genetic information for type 2 diabetes (T2D) prediction with polygenic scores (PGS) in ancestrally diverse, real-world US healthcare systems is unclear, especially for those at low clinical phenotypic risk for T2D. METHODS: We tested the association of PGS with T2D incidence in patients followed within a primary care practice network over 16 years in four hypothetical...

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Identifiers

PMID: 38671457
DOI: 10.1186/s13073-024-01337-0
PMCID: PMC11046943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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