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Type 2 diabetes genetic risk and incident diabetes across diabetes risk enhancers.

Diabetes, obesity & metabolism - 1 Mar 2025

Moura Filipe A, Kamanu Frederick K, Wiviott Stephen D, Giugliano Robert P, Udler Miriam S, Florez Jose C, Ellinor Patrick T, Sabatine Marc S, Ruff Christian T, Marston Nicholas A

Abstract excerpt

AIMS: To evaluate the predictive value of a contemporary type 2 diabetes (T2D) polygenic score (PGS) in detecting incident diabetes across a range of diabetes risk factors. MATERIALS AND METHODS: We analysed participants in the Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk (FOURIER) trial (ClinicalTrials.gov, number NCT0176463), which compared the efficacy of...

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PMID: 39696834
DOI: 10.1111/dom.16123

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PCSK9

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