Germline genetic regulation of the colorectal tumor immune microenvironment.

doi:10.1186/s12864-024-10295-1

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Article

Germline genetic regulation of the colorectal tumor immune microenvironment.

BMC genomics - 25 Apr 2024

Schmit Stephanie L, Tsai Ya-Yu, Bonner Joseph D, Sanz-Pamplona Rebeca, Joshi Amit D, Ugai Tomotaka, Lindsey Sidney S, Melas Marilena, McDonnell Kevin J, Idos Gregory E, Walker Christopher P, Qu Chenxu, Kast W Martin, Da Silva Diane M, Glickman Jonathan N, Chan Andrew T, Giannakis Marios, Nowak Jonathan A, Rennert Hedy S, Robins Harlan S, Ogino Shuji, Greenson Joel K, Moreno Victor, Rennert Gad, Gruber Stephen B

Abstract excerpt

OBJECTIVE: To evaluate the contribution of germline genetics to regulating the briskness and diversity of T cell responses in CRC, we conducted a genome-wide association study to examine the associations between germline genetic variation and quantitative measures of T cell landscapes in 2,876 colorectal tumors from participants in the Molecular Epidemiology of Colorectal Cancer Study (MECC). METHODS: Germline...

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Identifiers

PMID: 38664626
DOI: 10.1186/s12864-024-10295-1
PMCID: PMC11046907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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