Article
Tumour immune contexture and immune evasion in sporadic and Lynch syndrome-associated microsatellite unstable colorectal cancers.
British journal of cancer - 1 Apr 2026
Martin Samantha, Elomaa Hanna, Väyrynen Juha P, Ahtiainen Maarit, Wirta Erkki-Ville, Böhm Jan, Seppälä Toni T, Ristimäki Ari, Tahkola Kyösti, Mattila Anne, Koskensalo Selja, Renkonen-Sinisalo Laura, Lepistö Anna, Mecklin Jukka-Pekka, Palin Kimmo, Rajamäki Kristiina, Aaltonen Lauri A
Abstract excerpt
BACKGROUND: The high mutational burden in microsatellite unstable colorectal cancers (MSI CRCs) results in high immunogenicity, yet response rates to immunotherapy vary, suggesting underlying heterogeneity of the tumour immune landscape. Here, our aims were (1) to characterise the immune cell infiltrate and immune evasion in MSI CRCs, (2) to correlate these with clinical and genomic features, and (3) to compare...
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