Article
Mutations in the Drosophila alphaPS2 integrin subunit uncover new features of adhesion site assembly.
Developmental biology - 15 Aug 2007
Devenport Danelle, Bunch Thomas A, Bloor James W, Brower Danny L, Brown Nicholas H
Abstract excerpt
The Drosophila alphaPS2betaPS integrin is required for diverse development events, including muscle attachment. We characterized six unusual mutations in the alphaPS2 gene that cause a subset of the null phenotype. One mutation changes a residue in alphaPS2 that is equivalent to the residue in alphaV that contacts the arginine of RGD. This change severely reduced alphaPS2betaPS affinity for soluble ligand,...
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