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Microsatellite instability and mismatch repair protein deficiency: equal predictive markers?

9 Apr 2024

Abstract excerpt

Current clinical guidelines recommend mismatch repair (MMR) protein immunohistochemistry (IHC) or molecular microsatellite instability (MSI) tests as predictive markers of immunotherapies. Most of the pathological guidelines consider MMR protein IHC as the gold standard test to identify cancers with MMR deficiency and recommend molecular MSI tests only in special circumstances or to screen for Lynch syndrome....

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PMID: 38655493
DOI: 10.3389/pore.2024.1611719

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