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Deficient mismatch repair: Read all about it (Review)

12 Aug 2015

Abstract excerpt

Defects in the DNA mismatch repair (MMR) proteins, result in a phenotype called microsatellite instability (MSI), occurring in up to 15% of sporadic colorectal cancers. Approximately one quarter of colon cancers with deficient MMR (dMMR) develop as a result of an inherited predisposition syndrome, Lynch syndrome (formerly known as HNPCC). It is essential to identify patients who potentially have Lynch syndrome,...

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PMID: 26315971
DOI: 10.3892/ijo.2015.3119

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