Article
Defects in MMR Genes as a Seminal Example of Personalized Medicine: From Diagnosis to Therapy
8 Dec 2021
Abstract excerpt
Microsatellite instability (MSI) is the landmark feature of DNA mismatch repair deficiency, which can be found in 15-20% of all colorectal cancers (CRC). This specific set of tumors has been initially perceived as a niche for geneticists or gastroenterologists focused on inherited predispositions. However, over the years, MSI has established itself as a key biomarker for the diagnosis, then extending to...
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