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Testing for deficient mismatch repair and microsatellite instability

24 Oct 2023

Abstract excerpt

Testing to detect mismatch repair deficiency (dMMR) and high-grade microsatellite instability (MSI-H) has become an integral part of the routine diagnostic workup for colorectal cancer (CRC). While MSI was initially considered to be a possible indicator of a hereditary disposition to cancer (Lynch syndrome, LS), today the prediction of the therapy response to immune checkpoint inhibitors (ICI) is in the...

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PMID: 37874379
DOI: 10.1007/s00292-023-01208-2

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