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Mismatch Repair Protein Loss as a Prognostic and Predictive Biomarker in Breast Cancers Regardless of Microsatellite Instability

22 Sept 2018

Abstract excerpt

Abstract Background Breast cancers that harbor mismatch-repair (MMR) deficiency and/or microsatellite instability (MSI) might be sensitive to immune checkpoint blockade, but there are currently no specific guidelines for assessing MMR status in breast cancer. Here, we sought to define the clinical value of MMR immunohistochemistry (IHC) and MSI analysis in breast cancers. Methods We subjected 444 breast cancers...

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Cancer Immunotherapy and Biomarkers
Genetic factors in colorectal cancer
Multiple and Secondary Primary Cancers

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31360876
DOI: 10.1093/jncics/pky056

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