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Comparison of standard mismatch repair deficiency and microsatellite instability tests in a large cancer series

13 Feb 2024

Abstract excerpt

BACKGROUND: The tumor-agnostic indication of immune checkpoint inhibitors to treat cancers with mismatch repair deficiency (dMMR)/microsatellite instability (MSI) increased the demand for such tests beyond Lynch syndrome. International guideline recommendations accept immunohistochemistry (IHC) for dMMR or molecular techniques (PCR or NGS) for MSI status determinations considering the two tests are equal,...

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PMID: 38350968
DOI: 10.1186/s12967-024-04960-y

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