The role of cellular senescence and SASP in tumour microenvironment.

doi:10.1111/febs.16381

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Article

The role of cellular senescence and SASP in tumour microenvironment.

The FEBS journal - 1 Mar 2023

Takasugi Masaki, Yoshida Yuya, Hara Eiji, Ohtani Naoko

Abstract excerpt

Cellular senescence refers to a state of irreversible cell cycle arrest that can be induced by various cellular stresses and is known to play a pivotal role in tumour suppression. While senescence-associated growth arrest can inhibit the proliferation of cancer-prone cells, the altered secretory profile of senescent cells, termed the senescence-associated secretory phenotype, can contribute to the...

Topics

Humans
Tumor Microenvironment
Phenotype
Cellular Senescence
Neoplasms
Carcinogenesis

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Open in PubMed

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PMID: 35106956
DOI: 10.1111/febs.16381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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